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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
other: no data
GLP compliance:
no
Type of method:
flask method
Water solubility:
0.029 other: mol/L
Temp.:
25 °C
Remarks on result:
other: converted: 3.540 g/L
Conclusions:
The solubility of 2,5-xylenol in water was determined spectrophotometrically at 25 °C as 0.029 mol/L (3.540 g/L).
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
other: no data
GLP compliance:
no
Type of method:
other: colorimetric method and spectrophotometric method
Key result
Water solubility:
0.026 other: mol/L
Temp.:
25 °C
pH:
5.1
Remarks on result:
other: converted 3.18 g/L
Details on results:
For both methods, spectrophotometric method and colorimetric, the determination of solubility of 2,5-xylenol results in the same value.
Conclusions:
The solubility of 2,5-xylenol was measured with two different methods. Once photospectrometrically, once colorimetrically. The results derived from both determinations are the same: Solubility of 2,5-xylenol at 25 °C and a pH of 5.1 is 0.026 mol/L (3.18 g/L).
Endpoint:
water solubility
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Qualifier:
according to guideline
Guideline:
other: no data
GLP compliance:
no
Water solubility:
3.853 g/L
Temp.:
25 °C

Description of key information

0.029 mol/L (3.540 g/L) at 25 °C

(flask method, spectrophotometrically, peer reviewed)

The key value in g/L is converted from the published value 0.029 mol/L.

Key value for chemical safety assessment

Water solubility:
3.54 g/L
at the temperature of:
25 °C

Additional information

The values described in the supporting studies are in a similar range:

0.026 mol/L (3.18 g/L) at 25 °C and pH5.1 (flask method, spectrophotometrically and colorimetrically)

3.853 g/L, calculated with EpiSuite