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EC number: 945-518-6
CAS number: -
Acute eye irritation/corrosion study on a
similar substance 01 was carried out based on the guidelines OECD No.405
"Acute Eye Irritation/Corrosionand the EU B.5, "Acute
Toxicity - Eye irritation".
Single samples of approximately 99.6
mg of the similar substance (a volume of approximately 0.1 ml) were
instilled into one eye of each of three rabbits. Observations were made
1, 24, 48 and 72 hours and 7 and 14 days after instillation.
Vocalisation of two rabbits was noted
immediately after instillation, indicating pain. Therefore, the eyes of
the third rabbit were anaesthesised with a local anaestheticum.
Instillation of the test substance resulted in effects on the cornea,
iris and conjunctivae. Corneal injury was seen as opacity (maximum grade
1) and epithelial damage (maximum 25 % of the corneal area) in one
animal, which had completely resolved within 72 hours. Iridial
irritation (grade 1) was observed in all animals after 1 hour which
recurred in one animal after 48 hours. Irritation of the conjunctivae
was seen as redness, chemosis and discharge, which had completely
resolved within 14 days in all animals. Due to brown staining by the
test substance, scoring for conjunctival redness was prohibited in all
animals after 1 hour and was partly prohibited in one animal upto 72
hours. Brown staining of the conjunctivae and of the fur on the head and
paws, caused by the test substance, was noted during the observation
period. Remnants of the test substance were present in the eyes of all
animals on day 1 and on the outside of the eyelids of two animals
between 1 and 72 hours.
Acute eye irritation/corrosion study was
carried out based on the guidelines OECD No.405 "Acute Eye Irritation/Corrosionand
the EU B.5, "Acute Toxicity - Eye irritation".
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