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EC number: 945-518-6
CAS number: -
The study was carried out based on
the guidelines described int EC Commission Directive 92/69/EEC, Part
B.3, "Acute Toxicity Dermal" and OECD No.402, "Acute Dermal Toxicity".
The substance was administered to five Wistar rats of each sex by dermal
application at 2000 mg/kg
body weight for 24 hours. Animals
were subjected to daily observations and weekly determination of body
weight. Macroscopic examination was performed after terminal sacrifice
No mortality occurred. Brown
staining of various body parts (considered to be related to staining
properties of the test
substance) and/or chromodacryorrhoea
was noted among all animals between days 1 and 8. The body weight gain
during the observation period was within the range expected for rats
used in this type of study.
No abnormalities were found at
macroscopic post mortem examination of the animals.
The dermal LD50 value in Wistar rats
was established to exceed 2000 mg/kg body weight (actual dose 2176 mg/kg
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