Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Authoritative database

Data source

Reference
Reference Type:
other: Authoritative database
Title:
Acute oral toxicity of CAS No.: 128-80-3
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus, A Toxnet Database Lite-Browse-Advanced, 2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity of C.I. Solvent Green 3 in rat
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): C.I. Solvent Green 3
- Molecular formula (if other than submission substance): C28H22N2O2
- Molecular weight (if other than submission substance): 418.4938 g/mole
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report): C.I. Solvent Green 3
- Molecular formula (if other than submission substance): C28H22N2O2
- Molecular weight (if other than submission substance): 418.4938 g/mole
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
3660 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 660 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality observed
Mortality:
not specified
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to 3660 mg/kg bw when rat were treated with C.I. Solvent Green 3 orally.
Executive summary:

In a acute oral toxicity, rat were treated with C.I. Solvent Green 3 orally. 50 % mortality observed at3660mg/kg bw . Therefore,LD50 was considered to be 3660 mg/kg bw when rat were treated withC.I. Solvent Green 3 orally.