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EC number: -
CAS number: -
Three minute exposure period
Adjusted tissue mean value
# Freeze-killed tissues
One hour exposure period
The skin corrosion potential of OLEIC_DimerFA_TETA_PAA was evaluated in
a GLP study using the in vitro skin model EpiDermTM.
The study was conducted in accordance with guidelines OECD Test
Guideline 431 and EU Method B.40.
Duplicate EpiDermTM inserts were
treated with OLEIC_DimerFA_TETA_PAA, distilled water (negative control)
and 8N potassium hydroxide (positive control) for 3 minutes and 1 hour.
At the end of the treatment period, the tissues were washed with
phosphate buffered saline (PBS) and cell viability was assessed using
the MTT assay. The skin corrosivity potential was classified according
to the remaining cell viability obtained after test material treatment
with either of the two treatment times.
Skin viability after a three minute or one hour exposure to the test
article was 72% and 52%, respectively. Skin viability after a three
minute or one hour exposure to the positive control article was 24% and
12%, respectively, demonstrating appropriate performance of the assay.
Under the conditions of this study, the test article,
OLEIC_DimerFA_TETA_TEPA_PAA, was not considered to be corrosive to skin
in the in vitro skin model EpiDermTM.
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