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Toxicity to microorganisms

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Description of key information

By QSAR Toolbox version 3.3 predicted model the toxicity to micro organism (IGC50) in Tetrahymena pyriformis was estimated to be 122.513618469 mg/l for 48 hrs in static condition and in fresh water for test substance Tris(5-amino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonato(2-))dialuminium with Growth inhibition effect.

Key value for chemical safety assessment

EC50 for microorganisms:
122.514 mg/L

Additional information

Toxicity to micro organism was assessed for the target compound Tris(5-amino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonato(2-))dialuminium (CAS no 68475-50-3) and its related read- across. The summary of the results are presented below:

Toxic effects of the test compound Tris(5-amino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonato(2-))dialuminium (CAS no 68475-50-3) was predicted (SSS QSAR, 2016). The study was based on the effects of the test compound on the micro organism species Tetrahymena pyriformis in 48 hrs duration in a fresh water static system. The predicted data suggests the Inhibition growth concentration (IGC50) on the basis of growth inhibition to be 122.513618469 mg/L. This value concluded that the test compound Tris(5-amino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonato(2-))dialuminium does not exhibit toxicity to micro organism (Tetrahymena pyriformis) and is non hazardous to the aquatic environment.

Whereas experimental study (Chemophere. Vol. 28, No. 12, pp. 2203.2236, 1994) for read across substance 2-aminonaphthalene-1-sulphonic acid (Cas no. 81-16-3)indicate that the effect concentrations i.e EC50 of test substance for bacteria (unadapted biological waste water treatment plant) was found to be >10000 mg/l.

Same experimental source i.e Chemophere. Vol. 28, No. 12, pp. 2203.2236, 1994 also report the the study for another read across 6-amino 1,3-naphthalene-disulfonic acid (Cas no. 118-33-2)which indicate that the effect concentration (EC50) of test substance 6 amino-1,3 naphthalene –disulfonic acid for bacteria (unadapted biological waste water treatment plant) was found to be 1000 mg/l for 24 hrs. on the basis of inhibition effect.

Based on above available studies for target chemical and its relevant read across it is concluded that the substance Tris(5-amino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonato(2-))dialuminium (CAS no 68475-50-3) non toxic to micro organisms.