Registration Dossier
Registration Dossier
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EC number: 613-701-7 | CAS number: 6485-45-6
Endpoint summary
Administrative data
Description of key information
Irritation:
- skin: corrosive
- eye: corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
In a primary skin irritation study with undiluted 2,6-dimethyl-morpholine (75 % cis / 25 % trans-mixture; CAS 6485-55-8) two animals were treated for 3 min or 1 h using occlusive conditions BASF AG, 1981; Val. 2). An application site of 1x1 cm was covered with the liquid test substance. After the application time the skin was washed with water and water/Lutrol (1:1). The animals were observed for 8 days and skin changes were recorded daily. The application of the test substance for 3 min caused slight, reversible erythema. The application for 1 h caused moderate to severe edema and severe erythema. After 24 h, parchment and leather-like necrosis were observed. The observed effects are considered as full thickness necrosis. Full thickness necrosis is considered to be an irreversible effect.
Only mild irritating effects to skin were found in a further study with 2,6- dimethylmorpholine (CAS 141-91-3) where only limited data is provided (Smyth et al. 1962; Val. 2).
Eye irritation:
Highly irritating to corrosive effects to eyes were found in a study with 2,6-dimethylmorpholine (CAS 141-91-3) where only limited data is provided (Smyth et al. 1962; Val. 2).
In general, as the test substance corrosive the skin, it can be expected to have a similar effect on the eyes also.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
EU classification according to Annex VI of Directive 67/548/EEC: C; R34
GHS classification: Skin corrotion Cat. 1B (which implies "serious damage to eye cat 1").
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