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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source

Data source

Reference
Reference Type:
review article or handbook
Title:
Skin irritation test of chemical 2,5-Dichloronitrobenzene (RTECS - CZ5260000)
Author:
RTECS® is a United States trademark owned and licensed under authority of the U.S. Government
Year:
2015
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances): Prehled Prumyslove Toxikologie; Organicke Latky; Volume(issue)/page/year: , 601,1986

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Skin irritation test of chemical 2,5-Dichloronitrobenzene was conducted on rabbit according to standard draize test.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2, 5-Dichloronitrobenzene
- Molecular formula (if other than submission substance): C6-H3-Cl2-N-O2
- Molecular weight (if other than submission substance): 192.001 g/mol
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
24 hours
Observation period:
no data
Number of animals:
no data
Details on study design:
The test was performed according to standard draize procedure.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 hrs
Reversibility:
no data
Remarks on result:
other: mildly

Applicant's summary and conclusion

Interpretation of results:
irritating
Conclusions:
The test was performed according to standard draize procedure.
Executive summary:

Skin irritation test was conducted according to standard draize procedure for chemical 2,5-Dichloronitrobenzene.The test chemical was exposed to rabbit skin with dose concentration of 500 mg for 24-hrs.

 

Mild irritating effects were observed on skin of rabbit when exposed to test chemical 2,5-Dichloronitrobenzene for 24-hrs.