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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Determination of LD50 value (Dermal) of chemical 2,5-Dichloronitrobenzene
Author:
IFA (GESTIS)
Year:
2016
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Acute dermal toxicity of chemical 2,5-Dichloronitrobenzene was determined in rats
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2,5-Dichloronitrobenzene
- Molecular formula (if other than submission substance): C6-H3-Cl2-N-O2
- Molecular weight (if other than submission substance): 192.001
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The LD50 value was found to be >2000 mg/kg in rats exposed to chemical 2,5-Dichloronitrobenzene in acute dermal test.
Executive summary:

Acute dermal toxiciyt test was performed to evaluate lethality of chemical 2,5-Dichloronitrobenzene.The animals were exposed by dermal route with dose concentration of 2000 mg/kg.

The animal only showed only a decrease of their spontaneous activity.2000 mg/kg did not lead to any deaths for rats.

The LD50 value was found to be >2000 mg/kg in rats exposed to chemical 2,5-Dichloronitrobenzene in acute dermal test.