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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
other: secondary source
Title:
Initial Submission: The Toxicity of p-Chlor-o-Nitraniline, o-Chlor-p-Nitraniline, 2, 5-Dichloronitrobenzene, And 3, 4-Dichlornitrobenzene (Final Report) With Letter 031892 (Sanitized)
Author:
Dow Chemical Company - NTRL
Year:
1992
Bibliographic source:
Dow Chemical Company Report 24 March 1992 - NTRL report

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
2, 5-Dichloronitrobenzene was evaluated for its toxic nature upon its acute oral administration in Guinea pigs.
GLP compliance:
not specified
Test type:
other: No data available

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2, 5-Dichloronitrobenzene
- Molecular formula (if other than submission substance): C6-H3-Cl2-N-O2
- Molecular weight (if other than submission substance): 192.001 g/mol
- Substance type: Organic
- Physical state: Solid
- Purity: No data available

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 5% gum acacia solution
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 1200, 1000, 800, 600 and 500 mg/Kg
- Amount of vehicle (if gavage): No data available
- Justification for choice of vehicle: No data available
- Lot/batch no. (if required): No data available
- Purity: No data available

MAXIMUM DOSE VOLUME APPLIED: No data available

DOSAGE PREPARATION (if unusual): No data available

CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data available
Doses:
1200, 1000, 800, 600 and 500 mg/Kg
No. of animals per sex per dose:
14
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
800 mg/kg bw
Based on:
test mat.
Clinical signs:
2, 5 dichloronitrobenzene was fairly toxic and likewise produced some irritation in the kidneys.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute oral LD50 for the test material 2, 5 dichloronitrobenzene is found to be 800mg/Kg.
Executive summary:

2, 5-Dichloronitrobenzene was evaluated for its toxic nature upon its acute oral administration in Guinea pigs.

 

The test compoundwas fairly toxic and likewise produced some irritation in the kidneys.

 

The acute oral LD50 for the test material2, 5 dichloronitrobenzene is found to be 800mg/Kg.

 

According to the publication, the test material classifies as an acute toxicant Category 4 chemical.