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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case history
Adequacy of study:
supporting study
Study period:
1988
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication contained sufficient detail to be able to judge it reliable as supporting data.

Data source

Reference
Reference Type:
publication
Title:
Severe ethylene glycol butyl ether poisoning. Kinetic and metabolic pattern.
Author:
Rambourg-Schepens MO, Buffet M, Bertault R, Jaussaud M, Journe B, Fay R and Lamiable D,
Year:
1988
Bibliographic source:
Human Toxicol., 7, 187-189.

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: oral
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Not applicable - poisoning incident.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Substance contained in a window cleaner preparation containing 12% 2-butoxyethanol

Method

Subjects:
- Number of subjects exposed: 1
- Sex: female
- Age: 50 years
Route of exposure:
oral
Reason of exposure:
intentional
Exposure assessment:
estimated
Details on exposure:
Estimated intake 0.5 to 1.0g/kg in a single acute exposure
Medical treatment:
Artificial respiration. Frusemide administered on day 2.

Results and discussion

Clinical signs:
On admission to the intensive care unit, the patient was comatose.
Results of examinations:
Biochemically the subject presented with metabolic acidosis, hypokalaemia, a rise in serum creatinine level and a markedly increased urinary excretion of oxalate crystals. Heart rate and blood pressure normal. Moderate haemoglobinuria between days 3-6 and progressive erythropenia (RBC 3.12x10E12/l, Hc 28.6%, Hg 9.7g/l on day 10)
Outcome of incidence:
Patient discharged on day 10.

Any other information on results incl. tables

Overload of the normal metabolic pathway may have lead to cleavage of the ether linkage as an alternative pathway, leading to ethylene glycol and subsequently oxalic acid metabolites.

Applicant's summary and conclusion

Conclusions:
Acute exposure of a human to 0.5-1g/kg of 2-butoxyethanol cause marked but fully reversible effects.
Executive summary:

In a suicide attempt, a 50-year woman ingested 250-500 ml of a window cleaner containing 12 % of 2 -butoxyethanol, corresponding to about 0.5 to 1 g/kg bw. On admission to the intensive care unit, the patient was comatose. Biochemically she presented with metabolic acidosis, hypokalaemia, a rise in serum creatinine level and a markedly increased urinary excretion of oxalate crystals. The patient made a full recovery after 7 days