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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report Date:
1984

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
Using an in-vitro test system (rat plasma), metabolism of glykol monobutyl ether acetate to ethylene glykol monomethyl ether was investigated in relation to an internal standard with gas chromatography (GC).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Butylglykoletheracetat
- Physical state: liquid
- Analytical purity: > 99 %
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
other: in vitro, test compound was added to 500 µL plasma of rats
Vehicle:
water
Duration and frequency of treatment / exposure:
2 to 20 min
Doses / concentrations
Remarks:
Doses / Concentrations:
0.2 µL/500 µL plasma (0.4 ‰ v/v)
Positive control:
internal standard: ethylene glycol monomethylether

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parameters
Test no.:
#1
Toxicokinetic parameters:
half-life 1st: 0.96 minutes

Metabolite characterisation studies

Metabolites identified:
not measured

Any other information on results incl. tables

Butoxy ethyl acetate is deacetylated very rapidly to butoxyethanol in rat serum. Half-life of the substance in the rat plasma determined by gas chromatography was 0.96 minutes.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
It can be concluded that butoxyethyl acetate entering the blood is broken down very rapidly to the parent glycol ether 2-butoxyethanol (~95% within 4-5 minutes). The systemic toxicity of 2-butoxyethyl acetate will therefore be the same as the parent glycol ether 2-butoxyethanol.
Executive summary:

An in vitro study examined the rate of hydrolysis of 2 -butoxyethyl acetate (2BA) in rat blood plasma. 2BA was deacetylated very rapidly to butoxyethanol in rat serum with a half life of 0.96 minutes. It can be concluded that butoxyethyl acetate entering the blood is broken down very rapidly to the parent glycol ether 2-butoxyethanol (~95% within 4-5 minutes). The systemic toxicity of 2-butoxyethyl acetate will therefore be the same as the parent glycol ether 2-butoxyethanol.