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EC number: 203-865-4
CAS number: 111-40-0
The 96-hour LC50 value of 430 mg/L for diethylene triamine is taken from a valid exposure study with guppies (Poecilia reticulata).
Twelve acute freshwater fish studies were listed for this endpoint. Full
study reports were not available for all of these studies, so in these
cases, a Klimisch score of 4 was assigned based on the unavailability of
the original reference. Four studies were assigned
Klimisch scores of 3 based on study design flaws such as inappropriate
test temperature, inappropriate route of administration of the test
chemical, and failure to neutralize test solutions following the
addition of the test material. Three studies were
assigned Klimisch scores of 2. One of these studies
was conducted with medaka (Oryzias latipes) and reported a
48-hour LC50 of 1,000 mg/L diethylene triamine. Another study was
conducted with the golden orfe and reported a 96 -hour LC50 >500 mg/L
diethylene triamine. The third study was conducted with guppies (Poecilia
reticulata) and reported a 96-hour LC50 of 430 mg/L diethylene
triamine. The 96-hour LC50 value of 430 mg/L
for guppies was selected as the key parameter for this endpoint since
the test was conducted for 96 hours (verses 48 hours) and resulted in
the lower LC50 value.
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