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EC number: 203-180-0
CAS number: 104-15-4
Mortality: number of deaths at each dose: 2/5, 3/5 and 4/5 at 1250, 1600
and 2000 mg/kg for females, and 2/5 at 2000 mg/kg for males.
Time of death was Day 1 for all but one animal at 1600 mg/kg that died
on day 13.
Clinical signs: hypoactivity, hunched posture, irregular breathing were
observed in all animals from all dose groups on day 1 and was reversible
within 3 days for males at 2000 mg/kg. For females, the above symptoms
plus abnormal gait, ptosis and piloerection were seen in all animals at
1600 and 2000 mg/kg and were not reversible.
Necropsy findings: Red discolouration of the GI tract filled with blood,
white discolouration of the mucosa of the stomach and intestine, pale
adrenals, growing together of the stomach and nearby organs, stomach
haemorrhages and abdomen filled with fluid (in animals that died).
The acute Oral Toxicity of Toluene 4-sulphonic acid was assessed following official method OECD 401, Acute Oral Toxicity. The test was performed with three concentrations (1250, 1600 and 2000 mg a.i./kg for females rats; 2000 mg a.i./kg for males rats) administered by oral gavage. 2 of 5 males at 2000 mg/kg; 2 of 5, 3 of 5, and 4 of 5 females died at 1250, 1600 and 2000 mg/kg, respectively. Death almost always occurred within one day of dosing. Given the predominance of deaths occurring within the day of exposure and the necropsy findings, it is likely that the deaths were a result of the acidity / corrosivity of the test substance. The internal examination findings suggest a secondary effect (i.e., corrosion) rather than a chemical toxicity.
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