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EC number: 203-180-0
CAS number: 104-15-4
The statistically significant increase in
frequency of micronuclei is considered to be of no biological
relevance for the following reasons:
- The frequency of micronuclei at this
sampling time point (0.18%) is not above the frequency of micronuclei
of controls generally observed in this test laboratory (0.07 - 0.22%).
The statistical significance in this case is caused by the low
frequency of micronuclei in the control group (0.02%) which deviates
downwards from the so far observed frequencies for controls. After
addition of male and female animals of sampling time point 72 h into
one group there is no more a statistically significant difference.
- A delayed effect based on slow excretion
is improbable for sodium cumenesulphonate as sulphonic acids in
general are readily absorbed and do not show any tendency for
accumulation. But this kind of detention is regarded as prerequisite
to explain based on the kinetic of erythrocyte maturation an impact on
micronuclei frequency at sampling time point of 72 hours.
The results of the positive control affirm
the sensitivity of the mouse strain to mutagenic substances.The
frequency of micronuclei in polychromatic erythrocytes was
considerably increased compared to the control group.
Table 1: Results of in vivo micronucleus
test for male animals (mean ± standard deviation)
*p < 0.05
Table 2: Results of in vivo
micronucleus test for female animal (mean ± standard
Table 3: Results of in vivo micronucleus
test for male + female animals (mean ± standard deviation)
* p < 0.05
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