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EC number: 203-180-0
CAS number: 104-15-4
In the highest dose group (500 mg/kg bw/day) urine was acidic in both
males and females. Also at the highest dose, some of the males had
higher salivation production which was considered an irritation
reaction. Neither the acidic urine or salivation were considered
significant adverse effects (i.e., toxicologically relevant) in this
study. The NOEL would be 100 mg/kg bw/d and the NOAEL 500 mg/kg bw/d.
At > 98% purity, the NOAEL based on active ingredient would be nearly
the same; > 490 mg/kg bw/d.
The repeated oral toxicity of Toluene 4-sulphonic acid was assessed following official guideline OECD 407, Repeated Dose 28-day Oral Toxicity Study in Rodents. The test was performed on 25 males and 25 females rats with four concentration (4, 20, 100 and 500 mg/kg bw). No mortality were seen and it can be state that the daily administration of the tested item at the highest dosage led to slight intolerance reactions (salivation) in the male animals, which did not occur until the 26th day of the experiment. The excretion of urine with a low pH value in both sexes, on the other hand, is to be regarded as a physiological reaction to the administration of the acidic test substance. No other changes were observed that could be related to the administration of the test substance.
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