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EC number: 203-002-1
CAS number: 102-06-7
The result of the study showed that chronic exposure to
DPG stimulated pleen enlargement and that the rate of spleen enlargement
exponentially commensurated with in vivo and in vitro proliferation of
spleen cells. DNA synthesis, in response to DPG showed time-dependent
increases similar to spleen growth and cell proliferation kinetics.
Additionally, spleen cells from DPG-treated animals "modified" the
medium in which they were cultured and that when spleen cells from
control animals were incubated in these "modified" media., their rate of
proliferation almost approached that of the treated population. The
results of the study suggest that mouse spleen cells responded to direct
or indirect DPG treatment and that the mitogenic stimulus provided by
DPG paralleled increased DNA synthesis during and after exposure to the
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