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EC number: 203-002-1
CAS number: 102-06-7
The acute dermal toxicity of 1,3-Diphenyl Guanidine (DPG)
was evaluated in rabbits in a study performed following EU method B. 3.
A limit test was performed in which one group of five male and five
female rabbits received a single dermal application of DPG at a dose of
2000 mg/kg body weight. Following dosing, the rabbits were observed
daily and weighed weekly. A gross necropsy examination was performed on
all test animals at the time of death or scheduled euthanasia (day 15).
No mortality occurred during the study. The most notable
clinical signs were generally limited to transient dermal irritation at
the site of test article application. Body weight gain was exhibited by
all animals during the study. At necropsy on day 15, the pancreas or
pancreatic lymph nodes of 4/10 animals were noted to have an abnormal
red discoloration. The cause of this finding could not be determined. No
significant internai abnormalities were observed in the remaining
animals at necropsy.
The acute dermal LD0 of 1,3-Diphenyl Guanidine was
determined to be greater than 2000 mg/kg in the rabbit.
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