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EC number: 203-002-1
CAS number: 102-06-7
In a study performed by Bayer
AG in 1970 the determination of the acute toxicity of DPG to golden
orfes (Leuciscus idus) gave LC0 -72h = 1mg/l and a LC100 -48h =
10 mg/l. Nevertheless, this study is considered as not reliable due to
the tested period (48h) which was shorter than the recommended exposure
The acute toxicity of DPG
(1,3-diphenlylguanidine) toOryzias latipeswas investigated using
the Japanese Industrial Standard test (JIS K 0102 -1986 -71) (static or
semi-static; 25°C +/- 2°C; solubilizer not specified). A LC50 of 10 mg/l
was determined after a 48-h exposure. This study is considered as
invalid due to significant methodological deficiencies.
A data sheet of the Monsanto Company (1986) contains the
Pimephales promelas LC50 -96h = 4.2 mg/l
Lepomis macrochirus LC50 -96h = 9.6 mg/l
Salmo sp. LC50 -96h = 11 mg/l
Lastly, in an insufficiently documented study on Cyprinus
carpio (single oral administration in gelatine capsule; flow-through
system; 18°C), the following effects were observed by Loeb & Kelly
Dose in mg/kg bw
Effect / Test Duration
3.2; 6.0 and 8.7 mg/kg bw
no effects within 114 h
9.5 and 17 mg/kg bw
not specified symptoms after < 120 h, recovery after < 312 h
5.6 mg/kg bw
mortality after 71 h
9.5 and 70 mg/kg bw
not specified symptoms after >= 22 h, mortality after 125 h
Nevertheless, gavage of fish cannot be considered as
relevant for aquatic ecotoxicological hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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