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EC number: 203-002-1
CAS number: 102-06-7
Potential maternal, embryotoxic
and teratogenic effects of DPG were evaluated in this study in rats. DPG
was admixed in 0.5% aqueous Methocel and administered orally by gavage
to three groups of 25 bred Charles River COBS CD female rats as a single
daily dose from days 6 through 15 of gestation. Dose levels of5,
25 and 50 mg/kg/day were selected. For comparative purposes, 25 control
females were concurrently dosed with 0.5% aqueous Methocelon
a comparable regimen at 10ml/kg/day. Throughout gestation,
all females were observed twice daily for toxicity and body weights were
recorded at appropriate intervals. On day 20 of gestation, all surviving
females were sacrificed for Cesarean section; fetuses were weighed,
sexed and examined for external, skeletal and soft tissue anomalies and
unscheduled deaths occurred in any study group. Severe clinical signs oftoxicity,
decreased maternal body weights and body weight gains, a slight increase
in postimplantation loss and a significantly decreased mean fetal weight
were evident inthe50mg/kg/day
dose group. A slight increase in fetuses with reduced ossification
(associated with reduced fetal weights) and an increase in bent ribs
(attributed to maternal toxicity in this group) were observed at the 50
mg/kg/day dose level. Scattered, infrequent clinical findings and a
slightly reduced body weight gain over the treatment period (gestation
days 6-16) occurred at the 25 mg/kg/day dose level.The
5 mg/kg/day group was comparable to the vehicle control group in all
The infrequent occurrence and nature of the malformations were not
indicative of a teratogenic response in any dose group.
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