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EC number: 203-002-1
CAS number: 102-06-7
Dermal absorption, distribution and
metabolism of 1.3 -diphenylguanidine (DPG), widely used as an
accelerator in processing rubber and in food packaging, was studied in
adult female Sprague-Dawley rats. DPG shows 10% penetration through
clipped back skin of the rats in 5 days. The first-order dermal
absorption rate constant as determined by least square method was 0.021
+/- 0.002 d-1 (T1/2 = 33.6 days). Approximately 13% of the absorbed dose
remained in the body in 5 days. Retention in skin, muscle, liver,
intestine and fat contributed most to the body burden of DPG-derived
radioactivity in 5 days. All tissues showed tissue to blood ratios
greater than 1, with liver and intestine ratios of 26 at 5 days.
Approximately 61% of the absorbed dose was eliminated into urine and 27%
into feces in 5 days showing rapid clearance of absorbed DPG from the
body. HPLC analysis of urine revealed two major peaks (parent compound
and metabolite(s)). Within 72h, approximately 50% of the DPG-derived
radioactivity excreted in the urine was parent compound. After 72h, the
DPG-derived radioactivity in the urine was present in the form of a
single metabolite, and no parent compound was detected. No parent
compound was detected in feces. Two metabolites, neither of which
occurred in urine, were detected in feces. The HPLC analysis of the
radioactivity at the application site showed only parent compound.
Even though DPG shows slow dermal
penetration, this route of exposure needs to be considered in the risk
assessments besause of the suspected chronic toxicity of DPG.
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