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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited documentation; endpoint record transferred from IUCLID 4

Data source

Referenceopen allclose all

Title:
No information
Author:
Kel'man, G.Ya., Gig. Trud. Prof. Zabol. 9(8), 32-36 (1965)
Title:
No information
Author:
Kel'man, G.Ya., Soviet Rubber Technol. 24, 40-41 (1965)

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
20 w
Frequency of treatment:
4 h/d, daily
Doses / concentrations
Remarks:
Doses / Concentrations:
2.5, 12.5 mg/l
Basis:

Control animals:
other: no data specified
Details on study design:
Post-exposure period: 30 d

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
low dose: slight decrease in body weight gain, diminution of
the antitoxic function of the liver, recovery within 30
days; high dose: decrease in body weight gain, depression of
the antitoxic function of the liver, a lowering of
albumens and an increase of gamma-globulin concentrations,
reduction in the intensity of the gas exchange, recovery
within 30 days

Applicant's summary and conclusion