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EC number: 500-051-3
CAS number: 26780-96-1
In a weight-of evidence appraoch three water solubility studies were evaluated. The complex composition of the substance has been identified to be the limiting factor for the determination of an exact value for the water solubility. Only a small portion (less than 0.1 %) of the substance is considered to be soluble in water, indicating a water solubility of about or below 1 mg/L.
BAYER AG 1989
A water solubility value of 24 mg/L was given in the report based on
gravimetric detection. In the raw data the very low mass difference of
1.2 mg was obtained by two weightings of the relatively heavy
evaporating dish before and after evaporation of the water: 34.2583 g –
34.2571 g = 0.0012 g. It is obvious that even with a good and modern
analytical balance a high uncertainty of the result is expected. This
was the reason why the study director mentioned in the study report:
“Information on the water solubility can only be achieved with
As the analytical method was not precise enough for the determination of
the water solubility, the result should be handled only as a rough
estimation indicating that the substance has a low water solubility.
A water solubility value of 2.5 mg/L (pH5) and 3.2 mg/L (pH9) was given
in the report based on HPLC detection. Due to the difficulty in analysis
of the substance and uncertainty of the composition, the authors stated:
“Values of the aqueous solubilities should be considered estimates and
not true values. These values will be higher than the true solubilities
by an amount that depends on the degree of impurities present”. For this
reason the Registrant has evaluated the water solubility as <2.5 mg/L or
BAYER AG 1999
This study is a GLP water solubility test performed according to OECD
105 (column elution method). The water solubility of
(“TMQ dimer”) from a matrix of 1,2-Dihydro-2,2,4-trimethylquinoline,
oligomers was investigated. TMQ dimer is the main single component in
the UVCB substance with a concentration range of 10 to 25%. The sample
used in the study contained about 29.9% TMQ dimer. The water solubility
was analysed using a HPLC method yielding a result of <0.2 mg/L TMQ
dimer. The study director stated a water solubility of <1.0 mg/L for the
sum of oligomers.
Each of the three studies has some limitations concerning precision of
the analytical method, the limit of quantitation required for low water
solubility. Moreover, the chemical composition of the UVCB substance was
a source of uncertainty. Nevertheless, the studies were evaluated in a
weight-of evidence approach finally leading to the conclusion, that only
a small portion (<0.1%) of the substance may be soluble in water.
Aniline has been found to be present in a concentration range of 0 to
0.2% in the original UVCB substance. According to the physico-chemical
properties of Aniline (e.g. water solubility = 35 g/L) it is suggested
that this might be a constituent of the water soluble fraction.
The water solublity is estimated to be around or below 1 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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