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EC number: 500-051-3
CAS number: 26780-96-1
One female in the 5010 mg/kg survived; in the high dose group (7940
mg/kg) one male rabbit survived and one female rabbit died after 4 days.
Signs of intoxication: reduced appetite and activity (2-4 days in
survivors); the female in the high dose group showed increasing
weakness, collapse and death after 4 days.
Gross autopsy descendents: Hemorrhagic areas of lungs, liver
dislocation, enlarged gall bladder, slight dislocation of spleen and
kidney and gastro intestinal inflammation.
Survivors (14 days): viscera appeared normal
In an early study with limited documentation one rabbit was dosed with
5010 mg/kg bw and two rabbits were dosed with 7940 mg/kg in an acute
toxicity experiment. Animals were observed for 14 days. Clinical signs
were noted for all animals and gross autopsy of the survivors indicated
hemorrhagic areas of the lung, discoloration of liver, spleen and kidney
and inflammation of the gastrointestinal tract.
The rabbit in low dose group survived and one out of twoo rabbits in the
high dose group died after 4 days. No precise LD50 value can be
calculated but a cut-off LD50 can be estimated to be > 5010 mg/kg bw.
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