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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited documentation; endpoint record transferred from IUCLID 4

Data source

Reference
Title:
No information
Author:
Unpublished data, Southern Research Institute; copy from the|NTP study files, enclosure of a letter from Eastin, W. dated|September 2, 1994

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: no data

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Route of administration:
other: skin painting
Duration of treatment / exposure:
14 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
2, 20, 200, 1000 and 2000 mg/kg bw
Control animals:
yes, concurrent no treatment
Details on study design:
Post-exposure period: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
no mortality; mean terminal body weight reduction 
(>=200 mg/ kg (m/f), 20 mg/kg (f)); the principal gross
lesion was scaly skin at treatment site (> 2 mg/kg);
histopathological lesions of the treated skin (>= 20 mg/kg
both sexes) and thyroid (>= 200 mg/kg both sexes;
hyperplasia, follicular cell) (no further information
available from the abstract)

Applicant's summary and conclusion