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EC number: 500-051-3
CAS number: 26780-96-1
There are no experimental studies available.
TMQ is an organic solid pastille at room temperature with a melting
point of 48°C (Currenta, 2010) and a very low vapour pressure <4.8 *
10-6 hPa at 25°C (Monsanto, 1980). Therefore inhalation exposure to
vapour can be excluded.
TMQ is a complex reaction mass (Mw approx. 500 g/mol) with partially
undefined composition (UVCB). The fractions with log Pow lower than 5
accounted for 18% of the total area with an average log Pow of 3.9. The
rest had an average log Pow of 6.2. TMQ is expected to be mostly
insoluble in water (Bayer AG, 1989). Due to the physicochemical
properties intestinal absorption might be assumed. This is confirmed by
acute and chronic studies. NOEL for repeated dose toxicity is considered
to be 12 mg/kg-bw/day with target organs liver and adrenals.
As the acute dermal toxicity study in rabbits yielded signs of systemic
toxicity and mortality at 7940 mg/kg bw only, and the molecular mass of
approx. 500 g/mol is suggestive for low dermal absorption.
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