Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-051-3 | CAS number: 26780-96-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There are no experimental studies available.
TMQ is an organic solid pastille at room temperature with a melting point of 48°C (Currenta, 2010) and a very low vapour pressure <4.8 * 10-6 hPa at 25°C (Monsanto, 1980). Therefore inhalation exposure to vapour can be excluded.
TMQ is a complex reaction mass (Mw approx. 500 g/mol) with partially undefined composition (UVCB). The fractions with log Pow lower than 5 accounted for 18% of the total area with an average log Pow of 3.9. The rest had an average log Pow of 6.2. TMQ is expected to be mostly insoluble in water (Bayer AG, 1989). Due to the physicochemical properties intestinal absorption might be assumed. This is confirmed by acute and chronic studies. NOEL for repeated dose toxicity is considered to be 12 mg/kg-bw/day with target organs liver and adrenals.
As the acute dermal toxicity study in rabbits yielded signs of systemic toxicity and mortality at 7940 mg/kg bw only, and the molecular mass of approx. 500 g/mol is suggestive for low dermal absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
