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EC number: 221-906-4
CAS number: 3277-26-7
The test substance was tested for acute oral toxicity to rats in study
conducted according to OECD Test Guideline 423 and in compliance with
Three female Wistar rats were given a single oral gavage administration
of 2000 mg/kg bw 1,1,3,3-tetramethyldisiloxane. The rats were then
observed for fourteen days, after which they were sacrificed and subject
to gross necropsy. This process was then repeated with a further three
Over the course of the study, there were no deaths or overt signs of
systemic toxicity, besides piloerection and hunched posture, each seen
in one animal on day 1. No significant, treatment-related effect on body
weight was reported, and no macroscopic abnormalities were detected at
post mortem examination.
The acute oral LD50 in rats was determined to be greater than 2000 mg/kg
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