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EC number: 221-906-4
CAS number: 3277-26-7
The DNEL for systemic effects via the inhaled route is determined on the
basis of route-to route extrapolation from the oral combined repeated
dose toxicity study with the reproduction / developmental toxicity
screening test, conducted according to OECD Test Guideline 422 and in
compliance with GLP, with dimethylsilanediol (DMSD).
The following correction was made to the NOAEL (oral): Correction
respiratory volume rat (24 hour) 1/1.15 m3/kg bw/day. Therefore the
corrected NOAEC for repeated-dose systemic effects via the inhalation
route is: 250 mg/kg/day*(1/1.15) = 217 mg/m3.
The DNEL for systemic effects via the oral route is determined on the
basis of the oral combined repeated dose toxicity study with the
reproduction / developmental toxicity screening test, conducted
according to OECD Test Guideline 422 and in compliance with GLP, with
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