Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-372-2
CAS number: 2425-85-6
C.I Pigment Red 3 was tested for mutagenicity with the strains TA 100,
TA 1535, TA 1537 and TA 98 of Salmonella typhimurium.
The mutagenicity studies were conducted in the standard plate test (Ames
Test) and in a modified preincubation test (Prival Test). The studies
were performed in the absence and in the presence of a metabolizing
system derived from hamster liver homogenate. A dose range of 6
different doses from 4 microgram/plate to 5 000 microgram/plate was used
for the mutagenicity study. In a third independent experiment a dose
range of 7 different doses from 100 microgram/plate to 7 500
microgram/plate was used.
Control plates without mutagen showed that the number of spontaneous
revertant colonies was similar to that described in the 1iterature. All
the positive control compounds gave the expected increase in the number
of revertant colonies.
Toxicity: The test compound proved to be not toxic to the bacterial
strains. 5 000 microgram/plate was chosen as top dose level for the
a) Ames Test: Mutagenicity: In the absence of the metabolic activation
system the test com- pound did not show a dose dependent increase in the
number of revertants in any of the bacterial strains.
b) Prival Test: In the presence of hamster liver S-9 using the
preincubation method according to Prival C.I Pigment Red 3 induce a dose
dependent increase in the number of revertant colonies, with the tester
strain TA 1537.
Summarizing, it can be stated that C.I Pigment Red 3 is not mutagenic in
the standard plate test (Ames Test) but in the preincubation method to
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again