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EC number: 219-372-2
CAS number: 2425-85-6
The absorption of CI Pigment Red 3 (purity, 94.7 %) was studied in male Fischer 344 rats, seven to eight weeks of age, given the compound once at 11.8 mg/kg bw suspended in corn oil by gavage. Gut contents, faeces and various tissues were extracted 1, 4, 24 and 48 h after dosing and the amount of parent compound present was determined. None was found in blood, liver or kidneys, and it was concluded that the compound is not absorbed from the intestinal tract. Recovery after 48 h was 72.4% of the dose, suggesting that the compound may be partly degraded by intestinal bacteria. (The Working Group noted that absorption of cleavage products or metabolites was not analysed.)
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