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EC number: 242-056-0
CAS number: 18171-19-2
There are no skin sensitisation
data for 3-chloropropyl(dimethoxy)methylsilane (CAS
18171-19-2; EC No. 242-056-0).
Therefore, data have been read across from the structurally related
3-chloropropyl(diethoxy)methylsilane (CAS 13501-76-3; EC No. 236-828-6).
In a skin sensitisation study (Buehler test), conducted to OECD Test
Guideline 406 and in compliance with GLP (Hüls AG, 1997e, Reliability
Score 1), 3-chloropropyl(diethoxy)methylsilane was not sensitising to
the skin of guinea pigs. No local or systemic effects were observed in
sensitisation study conducted according to OECD Test Guideline 429 will
be conducted and added to the dossier when available.
No irritation was observed in any of the animals during the three
induction phases or the challenge phase.
There are no skin sensitisation data for
3-chloropropyl(dimethoxy)methylsilane. Therefore, data have been read
across from the structurally related
3-chloropropyl(diethoxy)methylsilane. The key study was conducted
according to OECD Test Guideline 406 and in compliance with GLP and was
the only skin sensitisation study available for the source substance.
The test substance was not sensitising to guinea pig skin (Huls AG,
At induction, 100% of the test substance in maize oil vehicle was
applied to the left flank region of the animals (day 0). This
application process was repeated in total three times (day 7 and 14).
The undiluted test substance was applied epicutaneously to the same area
for 6 h.
At challenge, on day 28 (two weeks after the last topical
induction application), 100 % of the test substance in maize oil as the
vehicle, was applied to the right flank region for 6 h. Evaluation of
sensitisation occurred 24 and 48 h after patch removal. No local or
systemic effects were observed and no irritation was observed in any of
the animals during the three induction phases or the challenge phase.
Skin sensitisation data are provided for the analogue substances
(3-chloropropyl)trimethoxysilane (CAS 2530-87-2, Hüls,
1993e) and (3-chloropropyl)triethoxysilane (CAS 5089-70-3,
Dow Corning Corporation, 1995) have been included in support of the
analogue group approach taken for this substance.
Section 13 of IUCLID for the read-across justification reports.
Based on read across data from
3-chloropropyl(dimethoxy)methylsilane is not classified as a skin
sensitiser according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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