Registration Dossier

Administrative data

Description of key information

In a skin irritation study conducted according to OECD test guideline 404 and GLP (LPT, 2002b), (3-chloropropyl)dimethoxymethylsilane was not irritating to the skin of Himalayan rabbits. There were no systemic effects. 
In an eye irritation study conducted according to OECD test guideline 405 and GLP (LPT, 2002c), (3-chloropropyl)dimethoxymethylsilane was not irritating to the eyes of Himalayan rabbits. There were no systemic effects.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The studies described are the only studies available for skin and eye irritation for this substance.


Justification for selection of skin irritation / corrosion endpoint:
The selected study is the only available skin irritation study for the registered substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.

Justification for selection of eye irritation endpoint:
The selected study is the only available eye irritation study for the registered substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.

Justification for classification or non-classification

Based on the available in vivo data, (3 -chloropropyl)dimethoxymethylsilane is not classified for skin or eye irritation according to Regulation (EC) No 1272/2008.