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EC number: 242-056-0
CAS number: 18171-19-2
1 % inhibition
Substance ID / Conc.
Time period of O2 measurement (minutes)
Start value mg O2/L
End value mg O2/L
pH before O2 Measurement
CPMDCS 360 mg/L
CPMDCS 300 mg/L
CPMDCS 240 mg/L
CPMDCS 180 mg/L
DCP 5 mg/L
DCP 15 mg/L
DCP 30 mg/L
Sum RC1+ RC2
Toxicity to microorganisms:
Activated sludge respiration inhibition 3-hour EC50 value of
400 mg/l and EC10 value of 197 mg/l (EC Guideline:
88/302/EC), read-across from an analogous substance.
There are no microorganism
toxicity data available for 3-chloropropyl(dimethoxy)methylsilane,
therefore good quality data for the analogous substance
dichloro(3-chloropropyl)methylsilane (CAS 7787-93-1, EC 232-136-3), have
been read across. The submission substance,
3-chloropropyl(dimethoxy)methylsilane, hydrolyses rapidly in contact
with water to form 3-chloropropyl(methyl)silanediol and methanol. The
read-across substance, dichloro(3-chloropropyl)methylsilane hydrolyses
very rapidly in contact with water to form
3-chloropropyl(methyl)silanediol and hydrochloric acid. Both substances
hydrolyse rapidly and share the same silanol hydrolysis product;
3-chloropropyl(methyl)silanediol. In view of the rapid hydrolysis of the
registered substance, it is the silanol hydrolysis product that is
relevant for environmental risk assessment.
does not have adverse effects on microorganisms (OECD 2004).
acid is not expected to have adverse effects on microorganisms in a
sewage treatment plant, where the pH is maintained within a favourable
and dichloro(3-chloropropyl)methylsilane are within an analogue group of
substances within which, in general there is no evidence of significant
toxicity to microorganisms.
This group consists of substances
containing a number of different functional groups but specific read
across is between substances with similar functionality.
table below presents microorganism toxicity data for substances relevant
to 3-chloropropyl(dimethoxy)methylsilane (CAS 18171-19-2, EC 242-056-0).
It is therefore considered valid
to read-across the results for dichloro(3-chloropropyl)methylsilane (CAS
7787-93-1) to fill the data gap for the registered substance since the
source and target substances generate the same silanol hydrolysis
product. Additional information is given in a supporting report (PFA
2013j) attached in Section 13.
Table: Microorganism toxicity data
for relevant substances
Result: E(I)C50 (mg/l)
Result: NOEC (or EC10/ EC20) (mg/l)
EC10 1.1 ml/lNote: WS predicted 14000
EC10 >2 ml/l
A 3-hour EC50 value and
NOEC value of 400 mg/l and 197 mg/l respectively, have been determined
for the effects of dichloro(3-chloropropyl)methylsilane (CAS 7787-93-1)
on the inhibition of respiration of wastewater treatment plant bacteria
based on nominal concentrations of the substance (Werner, 1997).
(2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany,
18-20 October 2004, Methanol, CAS 67-56-1
(2013j). Peter Fisk Associates, STP Microorganism toxicity Main Analogue
Group report, PFA.300.003.006
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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