Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-581-0 | CAS number: 108-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance 3-chloroaniline was found to be irritating in skin and eye category.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- The prediction is done using QSAR Toolbox version 2.3
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Irritation parameter:
- other: Primary irritation index (PII)
- Basis:
- mean
- Score:
- 1.74
- Reversibility:
- no data
- Remarks on result:
- other: Slightly irritating to the skin of rabbit.
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- By primary irritation index (PII) from QSAR, skin irritation score of 3-chloroaniline was estimated to be 1.74.Based on this score it infers that the substance 3-chloroaniline was found to be slightly irritating to the skin of rabbit.
- Executive summary:
By primary irritation index (PII) from QSAR, skin irritation score of 3-chloroaniline was estimated to be 1.74.Based on this score it infers that the substance 3-chloroaniline was found to be slightly irritating to the skin of rabbit.
Reference
The prediction was based on dataset comprised from the following descriptors: "Primary Irritation Index"
Estimation method: Taking average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b" ) and ("c" and "d" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(Cl)cc(N)ccc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Similarity boundary:Target: c1(Cl)cc(N)ccc1
Threshold=60%,
Dice(Atom pairs)
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= 1.12
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= 2.19
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Reversibility:
- fully reversible
- Remarks on result:
- other: 3-Chloroaniline caused slight to moderate irritation to the conjunctiva but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Reversibility:
- fully reversible
- Remarks on result:
- other: 3-Chloroaniline caused slight to moderate irritation to the cornea but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a standardized test on rabbits' eyes (according to OECD guideline 405), 3-Chloroaniline caused slight to moderate irritation to the conjunctiva and cornea but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.
- Executive summary:
In a standardized test on rabbits' eyes (according to OECD guideline 405), 3-Chloroaniline caused slight to moderate irritation to the conjunctiva and cornea but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
No.of various studies were reviewed for skin irritation with Klimish rating 2 & 4 for the target as well as the read across substances for CAS: 108-42-9 considering the weight of evidence approach.
The results for target substance as well as analogues are summarized as follows
Sr. No |
Irritation Parameter |
Species |
Interpretation of results |
Conclusions |
Sources |
1 |
Primary irritation index (PII) |
Rabbit |
Slightly irritating |
By primary irritation index (PII) from QSAR, skin irritation score of 3-chloroaniline was estimated to be 1.74.Based on this score it infers that the substance 3-chloroaniline was found to be slightly irritating to the skin of rabbit. |
Predicted data for CAS:108-42-9 |
2 |
Erythema and edema score |
- |
Mildly Irritating |
Skin irritation tests performed in accordance with OECD Test Guideline: "Mild erythema and edema were induced at 24 and 48 hours, with recovery observed by 72 hours." The substance 3-chloroaniline is thus considered "mildly irritating." |
Data from study report for CAS : 108-42-9 |
3 |
Overall irritation score |
Rabbit |
Mildly Irritating |
500 mg of m-toluidine applied to the skin of rabbits for 24 hrs, resulted in a mild irritation effect. |
Data from publication for RA CAS : 108-44-1 |
Based on the above results it can be concluded that substance CAS: 108-42-9 is expected to show the similar toxicological effect based on the effects observed on the other category members. Thus it is concluded that the substance 3-chloroaniline was found to be irritating (slight-mild) to the skin of rabbit. Based on these results it can be concluded that 3-chloroaniline is classified as a skin irritant in category 2 as per the CLP regulation.
Eye irritation
Based on various studies that were reviewed for eye irritation for the target as well as the read across substances for CAS: 108-42-9 considering the weight of evidence approach.
The results for target substance as well as analogues are summarized as follows
Sr.No |
Irritation Parameter |
Species |
Interpretation of results |
Conclusions |
Sources |
1 |
Conjunctivae score and cornea score |
Rabbit |
Slightly to moderately irritating |
In a standardized test on rabbits' eyes (according to OECD guideline 405), 3-Chloroaniline caused slight to moderate irritation to the conjunctiva and cornea but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes. |
Data from IFA GESTIS database for CAS :108-42-9 |
2 |
Cornea score |
- |
Irritating |
Based on the description in CERI Hazard Data 2000-35 (2001) of eye irritation tests performed in accordance with OECD Test Guideline: "Mild corneal lesion (irreversible) and moderate corneal irritation were observed." The substance 3-chloroaniline is thus considered "irritating" . |
Data from study report for CAS:108-42-9 |
3 |
Overall irritation score |
Rabbit |
Moderately irritating |
20 mg of m-toluidine applied to the eyes of rabbits for 24 hrs, resulted in a moderate irritation effect. |
Data from publication for RA CAS : 108-44-1 |
Based on the above results it can be concluded that substance CAS: 108-42-9 is expected to show the similar toxicological effect based on the effects observed on the other category members. Thus it is concluded that the substance 3-chloroaniline was found to be irritating (slight to moderate) to the eyes of rabbit. Based on these results it can be concluded that 3-chloroaniline is classified as an eye irritant in category 2 as per the criteria of CLP regulation.
Justification for selection of skin irritation / corrosion endpoint:
By primary irritation index (PII) from QSAR, skin irritation score of 3-chloroaniline was estimated to be 1.74.Based on this score it infers that the substance 3-chloroaniline was found to be slightly irritating to the skin of rabbit.
Justification for selection of eye irritation endpoint:
In a standardized test on rabbits' eyes (according to OECD guideline 405), 3-Chloroaniline caused slight to moderate irritation to the conjunctiva and cornea but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.