3-chloroaniline

Endpoint summary

Description of key information

The substance 3-chloroaniline shows acute toxicity effect by the oral,inhalation and dermal route in category 3.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Principles of method if other than guideline:

The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to rat by the oral route.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Species:

rat

Strain:

not specified

Sex:

not specified

Route of administration:

oral: unspecified

Vehicle:

not specified

Control animals:

not specified

Sex:

not specified

Dose descriptor:

LD50

Effect level:

256 mg/kg bw

Based on:

test mat.

Interpretation of results:

Toxicity Category III

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute oral lethal dose (LD50) of 3 -Chloroaniline in rat was found to be 256 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the oral route in category 3.

Executive summary:

The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to rat by the oral route. The rats were given the test substance by the oral route at a dose concentration of 256 mg/kg of 3-chloroaniline.The lethal dose (LD50) of 3 -Chloroaniline in rat was found to be 256 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the oral route in category 3.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

256 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Principles of method if other than guideline:

The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to mouse by the inhalative route.

GLP compliance:

not specified

Test type:

standard acute method

Species:

mouse

Strain:

not specified

Sex:

not specified

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

not specified

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

4 h

Control animals:

not specified

Sex:

not specified

Dose descriptor:

LC50

Effect level:

550 other: mg/m3

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: LC50=550 mg/m3,when converted into mg/L it is equivalent to 0.55 mg/L.

Interpretation of results:

Toxicity Category III

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The lethal concentration (LC50) of 3 -Chloroaniline in mouse by the inhalative route was found to be 550 mg/m3. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the inhalative route in category 3.

Executive summary:

The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to mouse by the inhalative route.The mouse were given the test substance by the inhalative route at a dose concentration of 550 mg/m3 of 3-chloroaniline.The lethal concentration (LC50) of 3 -Chloroaniline in mouse was found to be 550 mg/m3. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the inhalative route in category 3.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LC50

Value:

550 mg/m³ air

Quality of whole database:

The data is K4 level.The data has been obtained from the experimental study from the journal of ‘Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure'.

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Principles of method if other than guideline:

The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to cat by the dermal route.

GLP compliance:

not specified

Test type:

standard acute method

Species:

cat

Strain:

not specified

Sex:

not specified

Type of coverage:

not specified

Vehicle:

not specified

Control animals:

not specified

Sex:

not specified

Dose descriptor:

LD50

Effect level:

223 mg/kg bw

Based on:

test mat.

Interpretation of results:

Toxicity Category III

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute dermal lethal dose (LD50) of 3 -Chloroaniline in cat was found to be 223 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the dermal route in category 3.

Executive summary:

The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to cat by the dermal route.The cat were given the test substance by the dermal route at a dose concentration of 223 mg/kg of 3-chloroaniline.The lethal dose (LD50) of 3 -Chloroaniline in cat was found to be 223 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the dermal route in category 3.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

223 mg/kg bw

Quality of whole database:

The data is K4 level.The data has been obtained from the experimental study from the reliable journal ‘Gigiena Truda i Professional'nye Zabolevaniya'.

Additional information

Acute toxicity: oral

Based on various studies were reviewed for acute oral toxicity with Klimish rating 4 for the target as well as the read across substances for CAS: 108-42-9 considering the weight of evidence approach.

The results for target substance as well as analogues are summarized as follows

Sr. No	Endpoint	Effect values	Species	Sources
1	LD50	256 mg/kg bw	Rat	Data from Publication for CAS :108-42-9
2	LD50	250 mg/kg bw	Guinea pig	Data from publication for CAS: 108-42-9
3	LD50	280 mg/kg bw	Rat	Data from publication for RA CAS: 108-45-2

 

Based on the studies summarized in the above table for target substance 3-chloroaniline and the read across substance m-phenylenediamine, the acute oral lethal dose (LD50) value was found to vary between 250 mg/kg bw to 280 mg/kg bw which qualifies for acute toxicity via the oral route as per CLP regulation. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3-chloroaniline exhibits acute toxicity via the oral route in the category 3.

Acute toxicity: inhalation

Based on various studies were reviewed for acute toxicity via the inhalation route for the target substances for CAS: 108-42-9 considering the weight of evidence approach.

The results for target substance are summarized as follows

Sr. No	Endpoint	Effect values	Species	Sources
1	LC50	550 mg/m3	Mouse	Data from Publication for CAS :108-42-9
2	LC50	500 – 800 mg/m3	Rat	Data from publication for CAS: 108-42-9

 

Based on the studies summarized in the above table for target substance 3-chloroaniline, the lethal concentration (LC50) value was found to vary between 500-800 mg/m3 which qualifies for acute toxicity via the inhalation route as per CLP regulation. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3-chloroaniline exhibits acute toxicity via the inhalation route in the category 3.

 

Acute toxicity: dermal

Based on various studies were reviewed for acute dermal toxicity for the target substance for CAS: 108-42-9 considering the weight of evidence approach.

The results for target substance are summarized as follows

Sr. No	Endpoint	Effect values	Species	Sources
1	LD50	223 mg/kg bw	Cat	Data from Publication for CAS :108-42-9
2	LD50	250 mg/kg bw	Rat	Data from publication for CAS: 108-42-9

Based on the studies summarized in the above table for target substance 3-chloroaniline,the acute dermal lethal dose (LD50) value was found to vary between 223 mg/kg bw to 250 mg/kg bw which qualifies for acute toxicity via the dermal route as per CLP regulation. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3-chloroaniline exhibits acute toxicity via the dermal route in the category 3.

Justification for selection of acute toxicity – oral endpoint

The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to rat by the oral route. The rats were given the test substance by the oral route at a dose concentration of 256 mg/kg of 3-chloroaniline.The lethal dose (LD50) of 3 -Chloroaniline in rat was found to be 256 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the oral route in category 3.

Justification for selection of acute toxicity – inhalation endpoint

The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to mouse by the inhalative route.The mouse were given the test substance by the inhalative route at a dose concentration of 550 mg/m3 of 3-chloroaniline.The lethal concentration (LC50) of 3 -Chloroaniline in mouse was found to be 550 mg/m3. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the inhalative route in category 3.

Justification for selection of acute toxicity – dermal endpoint

The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to cat by the dermal route.The cat were given the test substance by the dermal route at a dose concentration of 223 mg/kg of 3-chloroaniline.The lethal dose (LD50) of 3 -Chloroaniline in cat was found to be 223 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the dermal route in category 3.

Justification for classification or non-classification

Based upon the study results and available information,the substance 3-chloroaniline shows acute toxicity effect via the oral,inhalation and dermal route in category 3 as per CLP regulation.