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EC number: 258-753-8
CAS number: 53770-52-8
Conclusion: The oral administration of the
test material to rats for 90 days suggests the following conclusions;
(i.) Death occurred in several animals in the group receiving 100 mg/kg,
the mortality rate being 5% for male and 10% for females animals. Within
the range of 0.1 to 10 mg/kg of administration, no death occurred.
(ii) There was no difference between the growth curve of the control
group and that of the group to which the drug was administered. Death
caused by inhibition of body: weight (hyosthenia) was found in several
individuals of the group receiving 100 mg/kg only and it may be
considered that such deaths could not be attributed directly to the test
material but to the exacerbation of infectious diseases of lung.
(iii) Neither hematologic analysis, biochemical analysis of serum nor
urinary analysis show any apparent influence of administration of the
(iv) Histopathological analysis shows mainly accidental, environmental
and nutritional abnormalities, the specific fluctuation by the
administration of the test material not being identified.
(v) From our investigation, we have found that the maximum safe dose of the
test material is 10 mg/kg/day, or 600 mg per day for one adult.
the mixture containing 80% zinc 3,5-bis(α-methylbenzyl)salicylate the
overall NOAEL was 10 mg/kg bw/day following 90 day exposure therefore,
for zinc 3,5-bis(α-methylbenzyl)salicylate, the overall NOAEL was 8
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