Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 258-753-8
CAS number: 53770-52-8
As a worst case, absorption of zinc 3,5-bis(α-methylbenzyl)salicylate in humans via the oral and inhalation routes is assumed to be 100%. Absorption by the dermal route is assumed to be 10% based on the substance having a molecular weight > 500.
Toxicokinetic parameters such as uptake, distribution, metabolism and
excretion form the essential toxicological profile of a substance. An
approximate indication of the toxicokinetic pattern can be gained from
the results of basic toxicity testing. The assessment of the
toxicokinetic properties of zinc 3,5-bis(α-methylbenzyl)salicylate
detailed below is based on the results obtained for the
physical/chemistry and toxicological endpoints.
In the acute oral toxicity study and the repeated dose toxicity studies
with the test substance, signs of toxicity were observed indicating that
the substance is absorbed by this route. As a worst case, absorption via
the oral route is assumed to be 100%. The molecular weight (754 to 757)
of the test substance is > 500. Consequently, absorption via the dermal
route is assumed to be 10%. Signs of systemic toxicity were observed in
the oral toxicity studies with the substance therefore it is likely that
the substance will also be absorbed if it is inhaled, however, the
likelihood that inhalable atmospheres may be generated is low. As a
worst case, absorption via the inhalation route is assumed to be 100%.
The substance is considered to be lipophilic (based on log Kow >0)
therefore it is likely to distribute into cells and the intracellular
concentration may be higher than extracellular concentration
particularly in fatty tissues. Zinc 3,5-bis(α-methylbenzyl)salicylate
contains zinc and zinc is distributed to all tissues and tissue fluids
The organic component of the test substance is likely to undergo
metabolism in the liver and other organs with the resultant metabolites
eliminated by the kidneys in the urine. Bioaccumulation of the test
substance is not expected based on its low log Kow value, water
solubility and predicted metabolism.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again