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EC number: 258-753-8
CAS number: 53770-52-8
An acute dermal toxicity study was performed with test item in CRL:(WI)
rats, in compliance with OECD Guideline No.: 402.
A limit test was carried out at 2000 mg/kg body weight (bw) in both
sexes (5 rats/sex). The test item was applied as supplied as a single
dermal 24-hour exposure followed by a 14-day observation period.
Sufficient water was used to dampen the test material to ensure good
contact with the skin.
Clinical observations were performed on all animals at 1 and 5 hours
after dosing and daily for 14 days thereafter. Body weight was measured
prior to dosing on Day 0 and on Days 7 and 14. Gross macroscopic
examination was performed on all animals at the end of the 2-week
observation period (Day 14).
The results of the study were summarized as follows:
Test item did not cause mortality at the dose level of 2000 mg/kg bw.
Systemic clinical signs
There were no systemic clinical signs noted in any animal throughout the
Local dermal signs
No local dermal signs were observed after treatment with the test item
during the 14 days observation period.
Body weight and body weight gain
There were no treatment related effects on body weight or body weight
gain during the observation period. However, a slight body weight loss
was noted in one female rat at the dose level of 2000 mg/kg bw between
Days 7 and 14.
No macroscopic observations were noted at a dose level of 2000 mg/kg bw.
The acute dermal median lethal dose (LD50) of the test item was found to
be greater than 2000 mg/kg body weight in male and female CRL:(WI) rats.
According to the CLP Regulation, the test item is not classified for
acute dermal toxicity.
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