Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Summary on IUCLID (HEDSET) in existing Chemicals

Data source

Reference
Reference Type:
secondary source
Title:
No information
Author:
Monsanto
Year:
2000
Bibliographic source:
Summary on IUCLID (HEDSET) in existing Chemicals

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
rabbit
Strain:
Dutch
Sex:
not specified

Administration / exposure

Type of coverage:
semiocclusive
Duration of exposure:
24 hours
Control animals:
not required

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 7 940
Based on:
test mat.

Any other information on results incl. tables

Certainly combined with the dermal corrosion irritation assay

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
ASA is not toxic by dermal application on rabbit. This confirm the low dermal penetration.
Executive summary:

With an LD50 > 7940 mg/kg in rabbit, ASA is not classified and did not justify any further study with rat.