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EC number: 200-064-1 | CAS number: 50-78-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well-conducted volunteer study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- On the metabolism and toxicity of methyl salicylate
- Author:
- Davison C; Zimmerman EF, Smith PK
- Year:
- 1 961
- Bibliographic source:
- J Pharmacol Expt Therap 132:207-211
Materials and methods
- Type of study / information:
- Oral absorption and hydrolysis in humans
- Endpoint addressed:
- basic toxicokinetics
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Plasma analyses for methyl salicylate and free salicylate after oral administration of the ester to humans.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl salicylate
- EC Number:
- 204-317-7
- EC Name:
- Methyl salicylate
- Cas Number:
- 119-36-8
- IUPAC Name:
- methyl salicylate
- Details on test material:
- - Name of test material: methyl salicylate
- Molecular formula: C8H8O3
- Substance type: Oily liquid
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- 4 men, 2 women
- Exposure assessment:
- measured
Results and discussion
- Results:
- After 15 min, the mean MeS and free salicylate values were 4.9 and 7.9 mg/l, respectively. After 90 min, these values were 2.8 and 10.5 mg/l, respectively. 30% MeS remained unhydrolysed at 15 minutes, and 21% at 90 minutes.
Any other information on results incl. tables
Table 1: Comparison of plasma salicylate levels in humans in mg/l (dose averaged 7 mg/kg as SA) after oral administration of MeS or ASA
Subject ID |
MeS administration |
ASA administration |
||||||
15 min |
90 min |
15 min |
90 min |
|||||
MeS |
Free Sal. |
Total Sal. |
MeS |
Free Sal. |
Total Sal. |
Total Sal. |
Total Sal. |
|
PS |
6.4 |
8.8 |
15.2 |
3.2 |
5.0 |
8.2 |
|
|
DC |
3.2 |
7.7 |
10.9 |
5.7 |
21.1 |
26.8 |
16.9 |
26.8 |
LE |
4.7 |
7.4 |
12.1 |
2.5 |
7.3 |
9.8 |
7.3 |
22.3 |
LS |
4.5 |
13.6 |
18.1 |
0 |
10.8 |
10.8 |
25.0 |
34.0 |
CD |
4.5 |
6.0 |
10.5 |
1.3 |
9.6 |
10.9 |
16.9 |
20.4 |
EZ |
6.3 |
4.4 |
10.7 |
4.1 |
9.1 |
13.2 |
25.0 |
18.4 |
Mean |
4.9 |
7.9 |
12.8 |
2.8 |
10.5 |
13.3 |
18.2 |
24.5 |
SD |
0.05 |
1.27 |
1.26 |
0.82 |
2.29 |
2.78 |
3.26 |
2.87 |
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, in humans, hydrolysis of MeS was demonstrated but was slower and less complete than that for ASA, with 30% MeS unhydrolysed at 15 minutes, and 21% at 90 minutes.
- Executive summary:
Davison et al. (1961) reported that oral consumption of 0.42 ml of methyl salicylate by 6 human volunteers resulted in the rapid appearance of salicylic acid in the plasma. At 15 and 90 min, salicylic acid was two and fourfold higher respectively than methyl salicylate in plasma. This is indicative of extensive hydrolysis during oral absorption. However, hydrolysis of MeS to free salicylate was slower and less complete than that of ASA, with 30% MeS unhydrolysed at 15 minutes, and 21% at 90 minutes.
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