Registration Dossier

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
no hazard identified

Marine water

Hazard assessment conclusion:
no hazard identified

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
36 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
no exposure of sediment expected

Sediment (marine water)

Hazard assessment conclusion:
no exposure of sediment expected

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
no exposure of soil expected

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Acute aquatic toxicity has been shown to be very low:

- neutralized substance EC50 48h in invertebrates > 1000 mg/L

- substance LC50 48h in fish > 1000 mg/L, so LC50 96h expected to be far higher than 100 mg/L

- substance EC50 72h in algae > 100 mg/L, at worst without neutralization

Chronic aquatic toxicity is similarly low, with the lowest NOEC (in Daphnia magna) far higher than 10 mg/L (ca. 60 mg/L) for the non-neutralized substance

As calculated by MacKay level I model, the substance is predicted to ge highly distributed (> 98%) in aquatic compartment. So sediment and soil hazard assessment was not considered as relevant, in addition to very low aquatic toxicity observed. Moreover, acetylsalicylic acid is readily biodegradable in aerobic as well as in anaerobic conditions, so the substance can be predicted not to be persistent in the environment.

Conclusion on classification

The substance is not classified as dangerous for environment on the following basis:

Acute aquatic toxicity has been shown to be very low:

- neutralized substance EC50 48h in invertebrates > 1000 mg/L

- substance LC50 48h in fish > 1000 mg/L, so LC50 96h expected to be far higher than 100 mg/L

- substance EC50 72h in algae > 100 mg/L, at worst without neutralization

The substance is readily biodegradable, both in aerobic and anaerobic conditions.

Log Kow is 1.19 allowng predicting no bioaccumulation potential.

Chronic aquatic toxicity is similarly low, with the lowest NOEC (in Daphnia magna) far higher than 10 mg/L (ca. 60 mg/L) for the non-neutralized substance