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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
Estimation for LC50 for CAS 96-97-9
Author:
Sustainability Support Services (Europe) AB
Year:
2013
Bibliographic source:
QSAR Toolbox version 3.1

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
5-nitrosalicylic acid
EC Number:
202-548-8
EC Name:
5-nitrosalicylic acid
Cas Number:
96-97-9
Molecular formula:
C7H5NO5
IUPAC Name:
5-nitrosalicylic acid
Details on test material:
- Name of test material (as cited in study report): 5-nitrosalicylic acid
- Substance type: Organic
- Physical state: solid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
nose only
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
No. of animals per sex per dose:
6 animals
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
1 255 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h

Any other information on results incl. tables






The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Takes average value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

(((("a" and ("b" and ( not "c") )  )  and "d" )  and "e" )  and ("f" and "g" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O by Chemical elements

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O by Chemical elements

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Group 16 - Sulfur S OR Group 17 - Halogens Cl OR Group 17 - Halogens F OR Group 17 - Halogens F,Cl,Br,I,At by Chemical elements

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis

Domain logical expression index: "e"

Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=10%,
Dice(Atom centered fragments)

Domain logical expression index: "f"

Parametric boundary:The target chemical should have a value of log Kow which is >= 2.36

Domain logical expression index: "g"

Parametric boundary:The target chemical should have a value of log Kow which is <= 4.37

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The 4 hrs acute inhalation median lethal concentration (LC50) of 5-nitrosalicylic acid in rat was found to be 1255mg/L.Acute toxicity of 5-nitrosalicylic acid to rat by the inhalation route indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the inhalative route within the doses mentioned.

Executive summary:

The 4 hrs acute inhalation median lethal concentration (LC50) of 5-nitrosalicylic acid in rat was found to be 1255mg/L.Acute toxicity of 5-nitrosalicylic acid to rat by the inhalation route indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the inhalative route within the doses mentioned.