Registration Dossier

Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
other: data from hydrolysed substance
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
substance 530-62-1 hydrolyses

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: 99%

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White

Test system

Vehicle:
water
Controls:
not specified
Amount / concentration applied:
100mg
Duration of treatment / exposure:
14d
Observation period (in vivo):
14d
Number of animals or in vitro replicates:
3 rabbits

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
14 d
Score:
3
Irritation parameter:
iris score
Basis:
mean
Time point:
14 d
Score:
2

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information
Conclusions:
MMAS (Modified Maximum Average Score) of imidazole: 59.3
Imidazole was irritant based on cornea opacity grade 3 and grade 2 effects on iris in one animal after 14 days.