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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: data from hydrolysed substance
Adequacy of study:
key study
Study period:
1996
Reliability:
1 (reliable without restriction)
Justification for type of information:
Substance 530-62-1 hydrolyses

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1956
Report Date:
1956

Materials and methods

Test guideline
Qualifier:
no guideline followed
Version / remarks:
own test
Principles of method if other than guideline:
Altough the animals have been observed for 7 days this does not invalidate the study as all mortalities occurred within one day.
Study meets generally accepted scientific principles. Observation period 7 days.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: 99%
Specific details on test material used for the study:
10%

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
No. of animals per sex per dose:
23
Details on study design:
Test condition: Test Animals
Rats (strain unspecified) were used.
Administration
The Test Substance was prepared in aqueous medium to give a
final concentration of 10% imidazole, pH 9.
Evaluation
The LD50 was calculated on the Test Substance.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
970 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

Result:         Signs of toxicity

Mortality (Dose in mg/kg bw: no. of animals that died/no. of

animals):

5000: 1/1

4000: 1/1

2000: 1/1

1260: 5/5

1000: 2/5

700: 1/5

500: 0/5

During acute toxicity studies signs observed in both mice and rats included convulsions, disequilibria, lateral

posture, death within one day.

Apathy, minor disequilibria, and accelerated respiration was noted in survivors.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria