Registration Dossier
Registration Dossier
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EC number: 208-488-9 | CAS number: 530-62-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: data from hydrolysed substance
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Substance 530-62-1 hydrolyses
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Version / remarks:
- own test
- Principles of method if other than guideline:
- Altough the animals have been observed for 7 days this does not invalidate the study as all mortalities occurred within one day.
Study meets generally accepted scientific principles. Observation period 7 days. - GLP compliance:
- no
Test material
- Reference substance name:
- Imidazole
- EC Number:
- 206-019-2
- EC Name:
- Imidazole
- Cas Number:
- 288-32-4
- Molecular formula:
- C3H4N2
- IUPAC Name:
- 1H-imidazole
- Test material form:
- other: 99%
Constituent 1
- Specific details on test material used for the study:
- 10%
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- No. of animals per sex per dose:
- 23
- Details on study design:
- Test condition: Test Animals
Rats (strain unspecified) were used.
Administration
The Test Substance was prepared in aqueous medium to give a
final concentration of 10% imidazole, pH 9.
Evaluation
The LD50 was calculated on the Test Substance.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 970 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Result: Signs of toxicity
Mortality (Dose in mg/kg bw: no. of animals that died/no. of
animals):
5000: 1/1
4000: 1/1
2000: 1/1
1260: 5/5
1000: 2/5
700: 1/5
500: 0/5
During acute toxicity studies signs observed in both mice and rats included convulsions, disequilibria, lateral
posture, death within one day.
Apathy, minor disequilibria, and accelerated respiration was noted in survivors.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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