Registration Dossier
Registration Dossier
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EC number: 268-597-2 | CAS number: 68130-55-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC test guideline B.9 Number L383A
- Deviations:
- yes
- Remarks:
- except sites were not occluded and residual test material not wiped off.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Hexanedioic acid, mixed esters with decanoic acid, heptanoic acid, octanoic acid and pentaerythritol
- EC Number:
- 268-597-2
- EC Name:
- Hexanedioic acid, mixed esters with decanoic acid, heptanoic acid, octanoic acid and pentaerythritol
- Cas Number:
- 68130-55-2
- Molecular formula:
- C36H64O10
- IUPAC Name:
- 6-[3-(decanoyloxy)-2-[(heptanoyloxy)methyl]-2-[(octanoyloxy)methyl]propoxy]-6-oxohexanoic acid
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.0, 125.0, 500.0 or 2000.0 mg/kg/day
- Duration of treatment / exposure:
- 5-Days a week for 4-weeks
- Observation period:
- 2 weeks
- Number of animals:
- Six groups of 10 males and 10 females
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks:
- The test material was not visibly irritating to the skin at the exposure site.
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material was not visibly irritating to the skin at the exposure site.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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