Registration Dossier
Registration Dossier
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EC number: 268-597-2 | CAS number: 68130-55-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC test guideline B.9 Number L383A.
- Deviations:
- yes
- Remarks:
- except sites were not occluded and residual test material not wiped off
- GLP compliance:
- yes
- Test type:
- other: 28-Day Dermal Toxicity in Rats
Test material
- Reference substance name:
- Hexanedioic acid, mixed esters with decanoic acid, heptanoic acid, octanoic acid and pentaerythritol
- EC Number:
- 268-597-2
- EC Name:
- Hexanedioic acid, mixed esters with decanoic acid, heptanoic acid, octanoic acid and pentaerythritol
- Cas Number:
- 68130-55-2
- Molecular formula:
- C36H64O10
- IUPAC Name:
- 6-[3-(decanoyloxy)-2-[(heptanoyloxy)methyl]-2-[(octanoyloxy)methyl]propoxy]-6-oxohexanoic acid
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 5 days/week for 4-weeks
- Doses:
- 0.0, 125.0, 500.0 or 2000.0 mg/kg/day
- No. of animals per sex per dose:
- Six groups of 10 males and 10 females
- Control animals:
- yes, concurrent no treatment
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no
- Clinical signs:
- other: Animals treated with test article exhibited no signs indicative of systemic toxicity. The test material was not visibly irritating to the skin at the exposure site.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 for the test substance is >2000 mg/kg bw.
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