Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 262-975-0 | CAS number: 61788-44-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Bioaccumulation : aquatic/sediments:
The growth-corrected BCFvalue for test chemical was determined to be 10395 L/kg and non-growth corrected BCF determined 6695 l/kg in a dietary bioaccumulation study with rainbow trout (Oncorhynchus mykiss). By considering the above mentioned BCF value test chemical is considered to be very bioaccumulative in nature.
Additional information
Bioaccumulation : aquatic/sediments:
Experimental study for target chemical and supporting predicted studies have been reviewed for bioaccumulation of test chemical endpoint and their results are summarized below.
To determine BCF value of test chemical a dietary bioaccumulation study was performed with rainbow trout (Oncorhynchus mykiss) was carried out with styrenated phenol. The substance tested was a mixture of distyrenated phenol (40 per cent by weight) and tristyrenated phenol (60 per cent by weight). The study consisted of a 10-day uptake period, during which the fish were fed a diet spiked with the test substance, followed by a 42-day depuration period where the fish were fed uncontaminated diet. Hexachlorobenzene was used as positive control. The spiked food was prepared by using solvent and fish oil. The test system used was a flow-through system.
One replicate was carried out per test group with each replicate consisting of 125 fish in either 140 litres of water (test substance exposure) or 110 litres of water (control and positive control group). The initial loading rates were therefore 0.57 g fish/litre/day for the group exposed to the mixture of di/tristyrenated phenol and 0.059 g fish/litre/day for the control and positive control group. A daily feeding rate of three per cent of the body weight was used during the study.The fish were observed daily for mortality, behaviour and other effects. The levels of distyrenated phenol and tristyrenated phenol in the exposed fish were determined analytically on days 0, 1, 5 and 10 of the uptake phase and days 1, 2, 4, 7, 14, 28 and 42 of the depuration phase (ten fish were analysed at each sampling point).
The uptake and depuration pattern for tristyrenated phenol shows increasing concentrations with time over the entire exposure period followed by decreasing concentrations during the depuration period thw growth-corrected depuration half-life in the fish was around 18.4 days. The growth-corrected BCFvalue for test chemical was determined to be 10395 L/kg and non-growth corrected BCF determined 6695 l/kg in a dietary bioaccumulation study with rainbow trout (Oncorhynchus mykiss). By considering the above mentioned BCF value test chemical is considered to be very bioaccumulative in nature.
Further, to corroborate the above study prediction was done by using BCFBAF Program (v3.00) model of EPI suite (2018) in this prediction the bio concentration factor (BCF) for test chemical distyrenated phenol was estimated to be 11440 L/kg wet-wt at 25 deg. c tristyrenated phenol. Therefore it is concluded that test chemical is very bioaccumulative in food chain.
In addition to it one prediction was done by using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical tristyrenated phenol is 3246 L/kg wet-wt at 25 deg. c which exceeds the bioconcentration threshold of 2000. Therefore it is concluded that test chemical bioaccumulative in food chain.
By considering results of all the studies mentioned above it is concluded that BCF value of test chemical is in range of 3246- 11440 L/kg. This range BCF value exceeds the bioconcentration threshold of 2000 which indicates that test chemical is very bioaccumulative in aquatic organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.