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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from authoritative database
Justification for type of information:
Data is from authoritative database
Qualifier:
according to
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Principles of method if other than guideline:
Aim of this study was to evaluate the effect of test chemical on the mobility of aquatic invertevbrates.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Details on test organisms:
- Common name: Water flea
Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h
Reference substance (positive control):
no
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
4.6 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: Other details not known
Validity criteria fulfilled:
no
Conclusions:
The effective concentration (EC50) value of test chemical in aquatic invertebrate (Daphnia magna) in a 48 hr study on the basis of mobility effect was observed to be 4.6 mg/L.
Executive summary:

Aim of this study was to evaluate the effect of test chemical on the mobility of aquatic invertevbrates. Test conducted for 48 hrs. The effective concentration (EC50) value of test chemical in aquatic invertebrate (Daphnia magna) in a 48 hr study on the basis of mobility effect was observed to be 4.6 mg/L. Thus considering the CLP Criteria for aquatic classification of the substance , it is concluded that test chemical exhibit short term toxicity to aquatic invertebrates (Daphnia sps.) and classified as aquatic chronic 2 category.

Description of key information

Aim of this study was to evaluate the effect of test chemical on the mobility of aquatic invertevbrate. Test conducted for 48 hrs. The effective concentration (EC50) value of test chemical in aquatic invertebrate (Daphnia magna) in a 48 hr study on the basis of mobility effect was observed to be 4.6 mg/L. Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that test chemical exhibit short term toxicity to aquatic invertebrates (Daphnia magna) and classified as aquatic chronic 2 category.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
4.6 mg/L

Additional information

Data available for test chemicals including structurally and functionally similar read across chemical, study has been reviewed to determine the short term toxicity of the test chemical on the growth and mobility of daphnia magna. The studies are as mentioned below:

 

Aim of this study was to evaluate the effect of test chemical on the mobility of aquatic invertevbrate. Test conducted for 48 hrs. The effective concentration (EC50) value of test chemical in aquatic invertebrate (Daphnia magna) in a 48 hr study on the basis of mobility effect was observed to be 4.6 mg/L. Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that test chemical exhibit short term toxicity to aquatic invertebrates (Daphnia magna) and classified as aquatic chronic 2 category.

 

Above study was supported by the second data from peer reviewed journal. Short term toxicity of test chemical were studied was observing the effect of test chemical on the intoxication of freshwater aquatic invertebrate. 10 neonates <24h old Daphnia pulex in each test chamber not fed during the test were used in the study. Test conducted under the static system for 48 hrs. Based on the intoxication of Daphnia pulex after the exposure of 48 hrs, the EC50 was observed to 1.44 mg/l. Based on the EC50 value, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.

 

Thus based on the above results, chemical consider to be toxic and thus classified as aquatic chronic 2 category as per the CLP classification criteria.