Registration Dossier
Registration Dossier
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Reaction mass of 5,5'-{(phenylmethanediyl)bis[benzene-4,1-diyl-diazene-2,1-diyl]}bis{1-[3-(dimethylamino)propyl]-4-methyl-6-oxo-3-(pyridinium-1-yl)-1,6-dihydropyridin-2-olate} hydrochloride and 5,5’-[3,4’-(phenylmethanediyl)diphenylene]bis(diazene-2,1-diyl)bis{1-[3-(dimethylamino)propyl]-4-methyl-6-oxo-3-(pyridinium-1-yl)-1,6-dihydropyridin-2-olate} hydrochloride
EC number: 700-312-3 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The substance registered has an IC50 of 217.4 mg/L and a NOEC of 78 mg/L in the sludge respiratory inhibition test.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 217.4 mg/L
- EC10 or NOEC for microorganisms:
- 78 mg/L
Additional information
A valid activated sludge respiration inhibition was conducted with the analogue substance. The applicability of the read across approach had been confirmed by the registrant via an expert statement (see IUCLID chapter 13).
The EC50 and the NOEC were determined to 223 mg/L and 80 mg/L, respectively. Based on the same molarity, for the substance registered the resulting IC50 was 217.4 mg/L and the NOEC was 78 mg/L.The target chemical therefore can exhibit a significant impact on the respiratory activity on wastewater sludge only at concentrations > 100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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