Registration Dossier
Registration Dossier
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EC number: 427-430-5 | CAS number: 54301-26-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study, no guideline followed
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- HPLC method
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- ca. 2.2
- Temp.:
- 20 °C
- Remarks on result:
- other: no more detail
- Details on results:
- Dead volume= 2.6 mL
log P= 1.025*k + 1.184
r²=0.97 - Conclusions:
- Log P of Lipacide UG is 2.2
- Executive summary:
The aim of this study was to determine the coefficient partition of the item Lipacide UG, using HPLC method and according to the GLP principle.
HPLC uses analytical colums with a solid phase containing long hydrcocarbon chain (eg C8, C18) bounded to silice.
Chemicals are eluted with different speed from the column. Hydrosoluble products are eluted first, and liposoluble the latest, proportionally to their wter- hydroocarbon partition coefficient.
Partition coefficient is given from the capacity coefficient k:
k=(tR-t0)/t0
tR= retention time
t0= dead time
log P= a*k+b
a and b coefficient deduced from the standard curve.
this curve is determined using chemical standards (Phenol, alcool cynammique, benzoate de methyle, 2,3-dichloranilline, Benzoate de phényl, Benzoate de benzyl.
Log P of Lipacide UG is 2.2
Reference
Description of key information
In compliance with Principles of Good Laboratory Practises(1981) using HPLC method the Log Pow of the test material was 2.2.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.2
- at the temperature of:
- 20 °C
Additional information
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