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Physical & Chemical properties

Partition coefficient

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partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP study, no guideline followed
no guideline followed
Principles of method if other than guideline:
HPLC method
GLP compliance:
Type of method:
HPLC method
Partition coefficient type:
Analytical method:
high-performance liquid chromatography
log Pow
Partition coefficient:
ca. 2.2
20 °C
Remarks on result:
other: no more detail
Details on results:
Dead volume= 2.6 mL
log P= 1.025*k + 1.184
Log P of Lipacide UG is 2.2
Executive summary:

The aim of this study was to determine the coefficient partition of the item Lipacide UG, using HPLC method and according to the GLP principle.

HPLC uses analytical colums with a solid phase containing long hydrcocarbon chain (eg C8, C18) bounded to silice.

Chemicals are eluted with different speed from the column. Hydrosoluble products are eluted first, and liposoluble the latest, proportionally to their wter- hydroocarbon partition coefficient.

Partition coefficient is given from the capacity coefficient k:


tR= retention time

t0= dead time

log P= a*k+b

a and b coefficient deduced from the standard curve.

this curve is determined using chemical standards (Phenol, alcool cynammique, benzoate de methyle, 2,3-dichloranilline, Benzoate de phényl, Benzoate de benzyl.

Log P of Lipacide UG is 2.2

Description of key information

In compliance with Principles of Good Laboratory Practises(1981) using HPLC method the Log Pow of the test material was 2.2.

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
20 °C

Additional information